Dose should be titrated so heart rate does not increase by >10% of baseline. Titrate to patient response (heart rate, presence of ectopic activity, BP, urine output, CVP, PCWP, cardiac index). Administer via infusion pump to ensure precise amount delivered. Infusion of dobutamine should be started at a low rate (0.5 to 1.0 g/kg/min) and titrated at intervals of a few minutes, guided by the patient's response, including systemic blood pressure, urine flow, frequency of ectopic activity, heart rate, and (whenever possible) measurements of cardiac output, central venous pressure, and/or pulmonary.
Rate: Based on patient's weight (see Route/Dosage section). Premixed infusions are already diluted and ready to use. Admixed infusions stable for 48 hr at room temperature and 7 days if refrigerated. Dilute 250–1000 mg in 250–500 mL of D5W, 0.9% NaCl, 0.45% NaCl, D5/0.45% NaCl, D5/0.9% NaCl, or LR. Find information on Dobutamine (Dobutrex) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action. Summarize interprofessional team strategies for improving care coordination and communication to advance diabetes management and improve outcomes by using dobutamine. Review the mechanism of action of dobutamine that leads to its therapeutic effects. Dobutamine is usually given after other heart medicines have been tried without success. 
Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle.
Continuous Infusion: Dilution: Vials must be diluted before use. Outline the adverse event profile for dobutamine. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugsBeta-blockers: possibly severe hypotension with beta-blockersDopaminergics: effects possibly enhanced by entacapone avoid concomitant use with rasagiline ADMINISTRATION Reconstition– Route Continuous IV infusion centrally via CRIP (or peripherally via a large vein) Rate of Administration Varies with dose CommentsDilute to at least 50 mL with sodium chloride 0.9% or glucose 5% (less than 5 mg/mL, ideally 0. <10 : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another 1 agonist), dobutamine is less prone to induce hypertension than is dopamine. 10 to 20 : Dose as in normal renal function Dobutamine is a direct-acting agent whose primary activity results from stimulation of the 1 -adrenoceptors of the heart, increasing contractility and cardiac output. 20 to 50 : Dose as in normal renal function Dobutamine injection is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation. half-life – normal/ESRD (hrs) :2–4 minutes/– DOSE IN RENAL IMPAIRMENT GFR (mL/MIN). Molecular weight :301.4 337.8 (as hydrochloride). Low dose dobutamine, with an initial dose of 2.5 mcg/kg/minute may facilitate recognition of myocardial viability in abnormal segments. Inotropic agent DOSE IN NORMAL RENAL FUNCTION 2.5–10 micrograms/kg/minute, increasing up to 40 micrograms/kg/minute according to response PHARMACOKINETICS 5 mcg/kg/minute continuous IV infusion titrate to 10, 20, 30, and 40 mcg/kg/minute continuous IV infusion at 3-minute intervals.
0 kommentar(er)
